New Research: Sialic Acids May Contribute to Inflammation & Disease

Dr. Roger Seheult of MedCram explains new research on Neu5Gc, a sialic acid molecule found in meat and dairy, and how it may contribute to severe COVID-19 symptoms, inflammation, and certain chronic diseases and cancers.Roger Seheult, MD is the co-founder and lead professor at MedCram https://www.medcram.comHe is Board Certified in Internal Medicine, Pulmonary Disease, Critical Care, and Sleep Medicine and an Associate Professor at the University of California, Riverside School of Medicine.Interviewer: Kyle Allred, Physician Assistant, Producer, and Co-Founder of MedCram.comThis video was recorded on May 13, 2021TOPICS IN THIS VIDEO INCLUDE:00:00 Introduction to sialic acids and why they’re important00:39 What are sialic acids?01:53 Introduction to Neu5Ac (in humans) & Neu5Gc (in other mammals)03:41 Why are Neu5Ac and Neu5Gc important?05:41 Human antibodies against Neu5Gc-glycans, chronic inflammation, & xenosialitis07:21 French NutriNet-Sante study and “Gcemic Index” of foods08:40 Does just red meat contain Neu5Gc? What about poultry, eggs, & fish?09:14 Neu5Gc intake differences in men & women10:26 Association between BMI, plant-based diets, & sialic acids13:02 Cycle of obesity & inflammation13:30 Biologic therapy & coronary inflammation14:51 Dr. Esselstyn’s work on diet & coronary artery disease16:01 Risks of meat consumption - processed versus unprocessed20:00 Health benefits of red meat consumption22:01 Summary of diets & associated outcomes, looking ahead to COVIDENCE UK StudyLINKS / REFERENCES:Mechanism of uptake and incorporation of the non-human sialic acid N-glycolylneuraminic acid into human cells (Journal of Biological Chemistry) | https://pubmed.ncbi.nlm.nih.gov/15557321/From “Serum Sickness” to “Xenosialitis”: Past, Present, and Future Significance of the Non-human Sialic Acid Neu5Gc (Frontiers in Immunology) | https://www.frontiersin.org/articles/10.3389/fimmu.2019.00807/fullAssociation between Neu5Gc carbohydrate and serum antibodies against it provides the molecular link to cancer: French NutriNet-Santé study (BMC) | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7510162/Adventist Health Study-2 (Loma Linda University Health) | https://adventisthealthstudy.org/studies/AHS-2Association of Biologic Therapy With Coronary Inflammation in Patients With Psoriasis as Assessed by Perivascular Fat Attenuation Index (JAMA) | https://pubmed.ncbi.nlm.nih.gov/31365032/A plant-based diet and coronary artery disease: a mandate for effective therapy (Journal of Geriatric Cardiology) | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466936/Meat consumption and risk of 25 common conditions: outcome-wide analyses in 475,000 men and women in the UK Biobank study (BMC) | https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-021-01922-9#citeasThe COVIDENCE UK Research Study has been developed in response to the outbreak of coronavirus disease (Queen Mary University of London) | https://www.qmul.ac.uk/covidence/about-the-covidence-uk-study/All coronavirus updates are at MedCram.com (including more discussion on: does red meat cause cancer, cardiovascular disease, sialic acid, dairy and red meat cancer, COVID 19 Vaccines, and more).SUBSCRIBE TO THE MEDCRAM YOUTUBE CHANNEL:https://www.youtube.com/user/MEDCRAMvideos?sub_confirmation=1Get notified of new videos by hitting the bell icon: MEDCRAM WORKS WITH MEDICAL PROGRAMS AND HOSPITALS:MedCram offers group discounts for students and medical programs, hospitals, and other institutions. Contact us at [email protected] if you are interested.MEDIA CONTACT: Media Contact: [email protected] contact info: https://www.medcram.com/pages/media-contactVideo Produced by Kyle AllredFOLLOW US ON SOCIAL MEDIA:https://www.facebook.com/MedCramhttps://twitter.com/MedCramVideoshttps://www.instagram.com/medcramDISCLAIMER:MedCram medical videos are for medical education and exam preparation, and NOT intended to replace recommendations from your doctor.#COVID19 #SialicAcid #Neu5Gc